Saxena M, Mustelin T
Laboratory of Signal Transduction, La Jolla Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
Semin Immunol. 2000 Aug;12(4):387-96. doi: 10.1006/smim.2000.0219.
MAP kinases function as key signal integration points for a vast number of external stimuli that affect the life and death of cells and are therefore subject to rigorous regulation. Here we review the numerous protein phosphatases that directly counteract MAP kinase activation. To simplify the complexity, we attempt to integrate the information into a 'sequential phosphatase model' of MAP kinase regulation.
丝裂原活化蛋白激酶（MAP激酶）作为大量影响细胞生死的外部刺激的关键信号整合点，因此受到严格调控。在此，我们综述了众多直接对抗MAP激酶激活的蛋白磷酸酶。为简化其复杂性，我们试图将这些信息整合到一个MAP激酶调控的“顺序磷酸酶模型”中。
