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聚合性IgA骨髓瘤、高脂血症和黄瘤病:又一例病例及文献复习

Polymeric IgA myeloma, hyperlipidaemia and xanthomatosis: a further case and review.

作者信息

Roberts-Thomson P J, Venables G S, Onitiri A C, Lewis B

出版信息

Postgrad Med J. 1975 Jan;51(591):44-51. doi: 10.1136/pgmj.51.591.44.

DOI:10.1136/pgmj.51.591.44
PMID:1099570
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2495678/
Abstract

A patient is described who had myeloma of the polymeric IgA variety, together with a striking hyperlipidaemia and xanthomatosis. Investigations into the protein and lipid abnormality failed to demonstrate any mechanism for the hyperlipidaemia. A review of the literature, however, validates this clinical entity and some of the suggested explanations are discussed.

摘要

本文描述了一名患有聚合性IgA骨髓瘤的患者,同时伴有显著的高脂血症和黄瘤病。对蛋白质和脂质异常的调查未能发现高脂血症的任何机制。然而,文献回顾证实了这一临床实体,并对一些提出的解释进行了讨论。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a924/2495678/7f66dbd8f15a/postmedj00289-0053-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a924/2495678/a1f8622aeaba/postmedj00289-0051-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a924/2495678/36e0d4fcea97/postmedj00289-0052-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a924/2495678/7f66dbd8f15a/postmedj00289-0053-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a924/2495678/a1f8622aeaba/postmedj00289-0051-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a924/2495678/36e0d4fcea97/postmedj00289-0052-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a924/2495678/7f66dbd8f15a/postmedj00289-0053-a.jpg

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1
Polymeric IgA myeloma, hyperlipidaemia and xanthomatosis: a further case and review.聚合性IgA骨髓瘤、高脂血症和黄瘤病:又一例病例及文献复习
Postgrad Med J. 1975 Jan;51(591):44-51. doi: 10.1136/pgmj.51.591.44.
2
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Liposomes have a direct effect on multiple myeloma: a Mendelian randomization study.脂质体对多发性骨髓瘤有直接影响:一项孟德尔随机化研究。
Front Oncol. 2024 Jun 11;14:1404744. doi: 10.3389/fonc.2024.1404744. eCollection 2024.
2
Clinical, biochemical, and immunohistochemical features of necrobiotic xanthogranulomatosis.渐进性坏死性黄色肉芽肿的临床、生化及免疫组化特征
J Clin Pathol. 2003 Jan;56(1):64-8. doi: 10.1136/jcp.56.1.64.
3
Autoantibodies to glucosylated proteins in the plasma of patients with diabetes mellitus.糖尿病患者血浆中糖基化蛋白的自身抗体。

本文引用的文献

1
[Generalized xanthomatosis with affection of the bone and diffuse plasma cell proliferation in the bone-marrow in essential hyperlipemia].
Virchows Arch Pathol Anat Physiol Klin Med. 1950;318(3):394-431. doi: 10.1007/BF00952334.
2
Xanthomatosis and myelomatosis.黄瘤病和骨髓瘤病。
Proc R Soc Med. 1962 Apr;55(4):318-9. doi: 10.1177/003591576205500415.
3
Myelomatosis with lipaemia and xanthomata.伴有脂血症和黄瘤的骨髓瘤
Br Med J. 1960 Mar 12;1(5175):781-3. doi: 10.1136/bmj.1.5175.781.
Proc Natl Acad Sci U S A. 1984 May;81(10):3204-8. doi: 10.1073/pnas.81.10.3204.
4
Plasma cholesterol concentration and extra lipid band in monoclonal gammopathies.单克隆丙种球蛋白病中的血浆胆固醇浓度及额外脂质带
Postgrad Med J. 1984 Jul;60(705):449-53. doi: 10.1136/pgmj.60.705.449.
4
AN UNUSUAL SERUM LIPOPROTEIN-GLOBULIN COMPLEX IN A PATIENT WITH HYPERLIPEMIA.一名高脂血症患者体内一种不寻常的血清脂蛋白 - 球蛋白复合物
Am J Med. 1965 Feb;38:286-97. doi: 10.1016/0002-9343(65)90183-x.
5
GAMMA-TYPE I MYELOMA AND XANTHOMATOSIS.γ型I期骨髓瘤与黄瘤病
Arch Intern Med. 1964 Nov;114:688-93. doi: 10.1001/archinte.1964.03860110158019.
6
PLANE XANTHOMA, HYPERCHOLESTEROLAEMIA AND MYELOMATOSIS.扁平黄瘤、高胆固醇血症与骨髓瘤
Proc R Soc Med. 1964 Oct;57:889-90.
7
MYELOMATOSIS WITH XANTHOMATOSIS MULTIFORME.伴有多形性黄瘤病的骨髓瘤
Can Med Assoc J. 1964 Aug 22;91(8):374-80.
8
MULTIPLE MYELOMA WITH XANTHOMA FORMATION. A REPORT OF A CASE.伴有黄瘤形成的多发性骨髓瘤。病例报告。
Arch Pathol. 1964 Apr;77:400-6.
9
PLASMA CELL MYELOMA: GAMMA GLOBULIN SYNTHESIS AND STRUCTURE. A REVIEW OF BIOCHEMICAL AND CLINICAL DATA, WITH THE DESCRIPTION OF A NEWLY-RECOGNIZED AND RELATED SYNDROME, "H-GAMMA-2-CHAIN (FRANKLIN'S) DISEASE.浆细胞骨髓瘤:γ球蛋白的合成与结构。生化与临床数据综述,兼述一种新发现的相关综合征,“H-γ-2链(富兰克林氏)病” 。
Medicine (Baltimore). 1963 Nov;42:357-84.
10
Myelomatosis with xanthomatosis.伴有黄瘤病的骨髓瘤病
Ann Intern Med. 1961 Jan;54:134-41.