Marien K J, Smeenk G
Br J Dermatol. 1975 Oct;93(4):407-15. doi: 10.1111/j.1365-2133.1975.tb06514.x.
A case of plane xanthomatosis associated with multiple myeloma and hyperlipoproteinaemia in a 62-year-old woman is reported. The patient had IgG type lambda paraproteinaemia and type II A hyperlipoproteinaemia. The IgG paraprotein showed binding activity against high-density lipoprotein. It could not be demonstrated that these paraprotein-lipoprotein complexes were responsible for the hyperlipidaemia. Microchemical analysis of pathological skin demonstrated a high content of triglycerides, similar to that in eruptive xanthomata. No correlation was found between the lipid composition of the xanthomatous skin and the serum lipid composition. The results obtained with an in vitro culture method showed that the paraprotein present in the patient's serum was synthesized in the bone marrow but not in the normal or pathological skin.
报道了一例62岁女性患有的伴有多发性骨髓瘤和高脂蛋白血症的平面型黄瘤病。该患者有IgG λ型副蛋白血症和II A型高脂蛋白血症。IgG副蛋白显示出对高密度脂蛋白的结合活性。无法证明这些副蛋白-脂蛋白复合物与高脂血症有关。对病理性皮肤的微量化学分析显示甘油三酯含量很高，类似于发疹性黄瘤中的情况。在黄瘤性皮肤的脂质组成与血清脂质组成之间未发现相关性。体外培养方法得到的结果表明，患者血清中的副蛋白是在骨髓中合成的，而不是在正常或病理性皮肤中合成的。
