雄激素不敏感综合征作为一种可能的共激活因子疾病。 - Suppr

Androgen-insensitivity syndrome as a possible coactivator disease.

作者信息

Adachi M, Takayanagi R, Tomura A, Imasaki K, Kato S, Goto K, Yanase T, Ikuyama S, Nawata H

机构信息

Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

出版信息

N Engl J Med. 2000 Sep 21;343(12):856-62. doi: 10.1056/NEJM200009213431205.

DOI:10.1056/NEJM200009213431205

PMID:10995865

Abstract

摘要

相似文献

Androgen-insensitivity syndrome as a possible coactivator disease.雄激素不敏感综合征作为一种可能的共激活因子疾病。

N Engl J Med. 2000 Sep 21;343(12):856-62. doi: 10.1056/NEJM200009213431205.

[Androgen-insensitivity syndrome as a possible coactivator disease].[雄激素不敏感综合征作为一种可能的共激活因子疾病]

Fukuoka Igaku Zasshi. 2001 Jul;92(7):258-65.

A novel explanation for resistance to androgens.对雄激素抵抗的一种新解释。

N Engl J Med. 2000 Sep 21;343(12):881-2. doi: 10.1056/NEJM200009213431210.

Androgen receptor mutations identified in prostate cancer and androgen insensitivity syndrome display aberrant ART-27 coactivator function.在前列腺癌和雄激素不敏感综合征中鉴定出的雄激素受体突变表现出异常的ART-27共激活因子功能。

Mol Endocrinol. 2005 Sep;19(9):2273-82. doi: 10.1210/me.2005-0134. Epub 2005 May 26.

In-vitro characterization of androgen receptor mutations associated with complete androgen insensitivity syndrome reveals distinct functional deficits.与完全性雄激素不敏感综合征相关的雄激素受体突变的体外特征揭示了不同的功能缺陷。

Sex Dev. 2008;2(2):73-83. doi: 10.1159/000129692. Epub 2008 Jun 20.

Gene symbol: AR. Disease: androgen insensitivity syndrome.基因符号：AR。疾病：雄激素不敏感综合征。

Hum Genet. 2006 Apr;119(3):361.

A novel mutation F826L in the human androgen receptor in partial androgen insensitivity syndrome; increased NH2-/COOH-terminal domain interaction and TIF2 co-activation.部分雄激素不敏感综合征中人类雄激素受体的一种新型突变F826L；氨基末端/羧基末端结构域相互作用增强及TIF2共激活作用增强

Mol Cell Endocrinol. 2008 Sep 24;292(1-2):69-78. doi: 10.1016/j.mce.2008.06.016. Epub 2008 Jul 5.

Impaired helix 12 dynamics due to proline 892 substitutions in the androgen receptor are associated with complete androgen insensitivity.雄激素受体中脯氨酸892位点的替代导致螺旋12结构域动力学受损，这与完全性雄激素不敏感相关。

Hum Mol Genet. 2006 Mar 15;15(6):921-31. doi: 10.1093/hmg/ddl009. Epub 2006 Jan 31.

Partial androgen insensitivity with phenotypic variation caused by androgen receptor mutations that disrupt activation function 2 and the NH(2)- and carboxyl-terminal interaction.由雄激素受体突变导致的部分雄激素不敏感，伴有表型变异，这些突变破坏了激活功能2以及氨基末端和羧基末端的相互作用。

Mech Ageing Dev. 2004 Oct-Nov;125(10-11):683-95. doi: 10.1016/j.mad.2004.08.007.

A naturally occurring mutation in the human androgen receptor of a subject with complete androgen insensitivity confers binding and transactivation by estradiol.一名完全雄激素不敏感患者的人类雄激素受体中自然发生的突变赋予了雌二醇结合和反式激活能力。

Mol Cell Endocrinol. 2007 Jan 15;263(1-2):79-89. doi: 10.1016/j.mce.2006.08.012. Epub 2006 Oct 2.

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GGN repeat length of the androgen receptor gene is associated with antral follicle count in Chinese women undergoing controlled ovarian stimulation.在中国接受控制性卵巢刺激的女性中，雄激素受体基因的GGN重复长度与窦卵泡计数相关。

Nan Fang Yi Ke Da Xue Xue Bao. 2025 Feb 20;45(2):213-222. doi: 10.12122/j.issn.1673-4254.2025.02.01.

What Does Androgen Receptor Signaling Pathway in Sertoli Cells During Normal Spermatogenesis Tell Us?支持细胞中雄激素受体信号通路在正常精子发生中的作用告诉了我们什么？

Front Endocrinol (Lausanne). 2022 Feb 24;13:838858. doi: 10.3389/fendo.2022.838858. eCollection 2022.

Exercise-induced myokines and their effect on prostate cancer.运动诱导的肌动蛋白及其对前列腺癌的影响。

Nat Rev Urol. 2021 Sep;18(9):519-542. doi: 10.1038/s41585-021-00476-y. Epub 2021 Jun 22.

The FKBP4 Gene, Encoding a Regulator of the Androgen Receptor Signaling Pathway, Is a Novel Candidate Gene for Androgen Insensitivity Syndrome.FKBP4 基因，编码雄激素受体信号通路的调节剂，是雄激素不敏感综合征的一个新的候选基因。

Int J Mol Sci. 2020 Nov 9;21(21):8403. doi: 10.3390/ijms21218403.

Dihydrotestosterone Regulates Hair Growth Through the Wnt/β-Catenin Pathway in C57BL/6 Mice and Organ Culture.双氢睾酮通过Wnt/β-连环蛋白信号通路调控C57BL/6小鼠及器官培养中的毛发生长。

Front Pharmacol. 2020 Jan 23;10:1528. doi: 10.3389/fphar.2019.01528. eCollection 2019.

Effects of androgen receptor mutation on testicular histopathology of patient having complete androgen insensitivity.雄激素受体突变对完全性雄激素不敏感患者睾丸组织病理学的影响。

J Mol Histol. 2017 Jun;48(3):159-167. doi: 10.1007/s10735-017-9714-7. Epub 2017 Mar 15.

Complete androgen insensitivity syndrome caused by a deep intronic pseudoexon-activating mutation in the androgen receptor gene.雄激素不敏感综合征由雄激素受体基因中的深内含子假外显子激活突变引起。

Sci Rep. 2016 Sep 9;6:32819. doi: 10.1038/srep32819.

Identification of an AR Mutation-Negative Class of Androgen Insensitivity by Determining Endogenous AR Activity.通过测定内源性雄激素受体（AR）活性鉴定一类AR突变阴性的雄激素不敏感症

J Clin Endocrinol Metab. 2016 Nov;101(11):4468-4477. doi: 10.1210/jc.2016-1990. Epub 2016 Sep 1.

The Long-Term Outcome of Boys With Partial Androgen Insensitivity Syndrome and a Mutation in the Androgen Receptor Gene.患有部分雄激素不敏感综合征且雄激素受体基因突变男孩的长期预后

J Clin Endocrinol Metab. 2016 Nov;101(11):3959-3967. doi: 10.1210/jc.2016-1372. Epub 2016 Jul 12.

Regulators of Androgen Action Resource: a one-stop shop for the comprehensive study of androgen receptor action.雄激素作用调节剂资源库：雄激素受体作用综合研究的一站式平台。

Database (Oxford). 2016 Feb 13;2016. doi: 10.1093/database/bav125. Print 2016.

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Androgen-insensitivity syndrome as a possible coactivator disease.

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