T细胞谱系命运：受受体信号引导？

T-cell lineage fate: instructed by receptor signals?

作者信息

von Boehmer H

机构信息

Harvard Medical School, Dana-Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA.

出版信息

Curr Biol. 2000 Sep 7;10(17):R642-5. doi: 10.1016/s0960-9822(00)00665-5.

DOI:10.1016/s0960-9822(00)00665-5

PMID:10996091

Abstract

Mechanisms of lineage choice represent a challenging problem in developmental biology. Recent studies have shown that different T-cell receptor signals can affect CD4 or CD8 lineage choice. Thus, all the ingredients for instructive mechanisms of lineage fate are in place but other mechanisms cannot be completely ruled out.

摘要

谱系选择机制是发育生物学中一个具有挑战性的问题。最近的研究表明，不同的T细胞受体信号可以影响CD4或CD8谱系选择。因此，谱系命运的诱导机制的所有要素都已具备，但其他机制也不能完全排除。