Department of Clinical Chemistry, Microbiology and Immunology, Ghent University Hospital, Ghent University, 9000 Ghent, Belgium.
Curr Top Microbiol Immunol. 2012;360:75-97. doi: 10.1007/82_2012_230.
Notch signaling is critical during multiple stages of T cell development in both mouse and human. Evidence has emerged in recent years that this pathway might regulate T-lineage differentiation differently between both species. Here, we review our current understanding of how Notch signaling is activated and used during human T cell development. First, we set the stage by describing the developmental steps that make up human T cell development before describing the expression profiles of Notch receptors, ligands, and target genes during this process. To delineate stage-specific roles for Notch signaling during human T cell development, we subsequently try to interpret the functional Notch studies that have been performed in light of these expression profiles and compare this to its suggested role in the mouse.
Notch 信号通路在人和小鼠的 T 细胞发育的多个阶段都至关重要。近年来的证据表明，该通路可能在两种物种之间调节 T 细胞谱系分化的方式存在差异。在这里，我们综述了目前对于 Notch 信号通路在人类 T 细胞发育过程中如何被激活和使用的理解。首先，我们在描述 Notch 受体、配体和靶基因在这一过程中的表达谱之前，先描述了组成人类 T 细胞发育的发育步骤。为了阐明 Notch 信号在人类 T 细胞发育过程中的特定阶段的作用，我们随后尝试根据这些表达谱来解释已完成的 Notch 功能研究，并将其与在小鼠中的作用进行比较。
