Castro-Gago M, Novo-Rodríguez M I, Pintos-Martínez E, Campos Y, Arenas J, Eirís-Puñal J
Departamento de Pediatría, Hospital Clínico-Universitario, Complejo Hospitalario Universitario, SERGAS, Santiago de Compostela, España.
Rev Neurol. 2000;31(3):263-82.
We carry out a review of the current basic genetic, biochemical, clinical, diagnostic and therapeutic aspects of mitochondrial cytopathies due to deficiencies in the mitochondrial respiratory chain complexes, which appear clinically during childhood and/or adolescence.
The clinical description has been divided into two groups: mitochondrial cytopathies secondary to alterations of mitochondrial DNA (mtDNA) and mitochondrial cytopathies secondary to alterations of the nuclear DNA (nDNA); we also consider about the importance of such conditions at this age.
