de Lignières B, MacGregor E A
Hôpital Necher, Paris, France.
Cephalalgia. 2000 Apr;20(3):164-9. doi: 10.1046/j.1468-2982.2000.00037.x.
Menopause, the permanent cessation of menstruation, is due to ovarian failure, which may lead to oestrogen deficiency diseases, particularly osteoporosis, cardiovascular disease and cerebrovascular disease. Mortality and morbidity caused by these conditions can be modified by using hormone replacement therapy, but the benefits of this therapy must be weighed against the increased risk of breast cancer and the symptomatic side-effects the treatment may cause. The combination of transdermal oestrogen and natural progesterone offers the most favourable risk-to-benefit profile.
绝经是指月经永久性停止，它是由卵巢功能衰竭引起的，这可能会导致雌激素缺乏相关疾病，尤其是骨质疏松症、心血管疾病和脑血管疾病。使用激素替代疗法可以改变这些疾病所导致的死亡率和发病率，但这种疗法的益处必须与乳腺癌风险增加以及治疗可能引起的症状性副作用相权衡。经皮雌激素与天然孕酮联合使用时，风险效益比最为有利。
