A facile synthesis of cis-9-[4-(1,2-dihydroxyethyl)-cyclopent-2-enyl]guanine and its derivative.
作者信息
An G I, Rhee H
机构信息
Department of Chemistry, Hanyang University, Ansan, Kyunggi-do, Korea.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2000 Jul;19(7):1111-22. doi: 10.1080/15257770008035034.
PMID:10999251
Abstract
The synthesis of carbocyclic nucleosides, cis-9-[4-(1,2-dihydroxyethyl)-cyclopent-2-enyl]guanine (3) and cis-2-amino-6-cyclopropylamino-9-[4-(1,2-dihydroxyethyl)- cyclopent-2- enyl]purine (4), was achieved from cyclopentadiene (5) in five and six steps, respectively. This route involves a hetero Diels-Alder reaction and a Pd(0)-catalyzed coupling reaction.
摘要
Zotero 插件