肉毒杆菌毒素药物治疗：利用自然界最强大的神经毒素。
Pharmacotherapy with botulinum toxin: harnessing nature's most potent neurotoxin.
作者信息
Bell M S, Vermeulen L C, Sperling K B
机构信息
Valley Children's Hospital, Madera, California, USA.
出版信息
Pharmacotherapy. 2000 Sep;20(9):1079-91. doi: 10.1592/phco.20.13.1079.35040.
Botulinum toxin (BTX), a potent biologic neurotoxin, commonly is associated with lethal outbreaks of food poisoning; however, it also plays a role as a therapeutic agent. Since the 1970s physicians have investigated BTX therapy in patients with neurologic disorders. The number of applications greatly expanded over the years to include certain focal dystonias (blepharospasm, torticollis, laryngeal dystonias, writer's cramp), strabismus, and a wide variety of other indications (gastrointestinal disorders, cosmetic wrinkle correction, spasticity, hyperhidrosis). BTX's safety and efficacy are reviewed.
肉毒杆菌毒素（BTX）是一种强效生物神经毒素，通常与致命的食物中毒暴发有关；然而，它也具有治疗作用。自20世纪70年代以来，医生们一直在研究将BTX用于治疗神经系统疾病患者。多年来，其应用范围大幅扩大，包括某些局灶性肌张力障碍（眼睑痉挛、斜颈、喉部肌张力障碍、书写痉挛）、斜视以及各种各样的其他适应症（胃肠道疾病、美容除皱、痉挛、多汗症）。本文对BTX的安全性和有效性进行了综述。
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