Tan A K
Department of Neurology, Tan Tock Seng Hospital, Singapore.
Singapore Med J. 1998 Sep;39(9):403-5.
This study was done to examine the usefulness of botulinum toxin A injections in treating various neurological disorders such as hemifacial spasm, blepharospasm, focal dystonia and task-specific dystonia.
This was a prospective, open-labelled trial of patients seen in a Movement Disorders Clinic with dyskinesias potentially treatable with botulinum toxin. All patients were assessed before and after injections using clinical rating scales, and those with focal and task-specific dystonias were also recorded on videotape.
There were 102 patients with hemifacial spasm, 3 with blepharospasm, 13 with neck dystonia, 6 with writer's cramp, I with musician's cramp, and I with jaw dystonia. All patients with hemifacial spasm and blepharospasm obtained good results, while 77% of those with cervical dystonia received substantial benefit. Only half of those with writer's cramp improved. Hemifacial spasm seems more prevalent in Singapore compared with Western populations.
Injections of botulinum toxin are useful in treating the various neurological disorders studied. This is an advancement in the treatment of these dyskinesias which respond poorly to oral medications.
本研究旨在探讨A型肉毒杆菌毒素注射治疗多种神经系统疾病的有效性，如半面痉挛、眼睑痉挛、局限性肌张力障碍和任务特异性肌张力障碍。
这是一项针对运动障碍门诊中可能可用肉毒杆菌毒素治疗的运动障碍患者的前瞻性开放标签试验。所有患者在注射前后均使用临床评分量表进行评估，患有局限性和任务特异性肌张力障碍的患者还被录像记录。
有102例半面痉挛患者、3例眼睑痉挛患者、13例颈部肌张力障碍患者、6例书写痉挛患者、1例音乐家痉挛患者和1例下颌肌张力障碍患者。所有半面痉挛和眼睑痉挛患者均取得良好效果，而77%的颈部肌张力障碍患者获得显著益处。只有一半的书写痉挛患者有所改善。与西方人群相比，半面痉挛在新加坡似乎更为普遍。
肉毒杆菌毒素注射对所研究的各种神经系统疾病有效。这是这些对口服药物反应不佳的运动障碍治疗方面的一项进展。
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