Brandt B, Doyle B, Weintraub H, Harrison H
Ann Thorac Surg. 1975 Sep;20(3):308-15. doi: 10.1016/s0003-4975(10)64223-3.
Use of the membrane oxggenator has been advocated in the management of severe respiratory insufficiency. We have compared this method to conventional therapy in an experimental model in which 23 dogs were subjected to aspiration with 0.1 N HC1 and 18 were supported with a volume respirator and positive end-expiratory pressure or placed on partial bypass using a membrane oxygenator for 12 to 24 hours. Adequate oxygenation (POX greater than 100 mm Hg) was achieved with the membrane oxygenator. The increase in lung weight during conventional therapy was significantly greater than during membrane oxygenator support. Extracorporeal support during recovery from severe pulmonary injury allows pulmonary artery pressure to be controlled and reduces the expected increase in lung water.
膜式氧合器已被提倡用于治疗严重呼吸功能不全。我们在一个实验模型中将这种方法与传统疗法进行了比较，在该模型中，23只狗被用0.1N盐酸进行吸入处理，18只狗用容量呼吸器和呼气末正压进行支持，或者使用膜式氧合器进行部分体外循环12至24小时。使用膜式氧合器可实现充分的氧合（动脉血氧分压大于100mmHg）。传统疗法期间肺重量的增加显著大于膜式氧合器支持期间。严重肺损伤恢复过程中的体外支持可控制肺动脉压，并减少预期的肺水增加。
