Cohibins C and D, two important metabolites in the biogenesis of acetogenins from Annona muricata and Annona nutans.

作者信息

Gleye C, Raynaud S, Fourneau C, Laurens A, Laprévote O, Serani L, Fournet A, Hocquemiller R

机构信息

Laboratoire de Pharmacognosie, UPRES-A CNRS 8076 (BioCIS), Faculté de Pharmacie, Université Paris XI, 92296 Châtenay-Malabry Cedex, France.

出版信息

J Nat Prod. 2000 Sep;63(9):1192-6. doi: 10.1021/np000061a.

DOI:10.1021/np000061a

PMID:11000017

Abstract

Two new annonaceous acetogenins, cohibins C (1a) and D (1b), have been isolated by extensive chromatography of a hexane extract of Annona muricata seeds and a cyclohexane extract of Annona nutans root bark. Their structures have been established on the basis of spectral evidence (NMR, MS) and confirmed by chemical transformation into a pair of monotetrahydrofuran (mono-THF) acetogenins. The role of these compounds in the biogenesis of mono-THF acetogenins is discussed.

摘要