Liaw Chih-Chuang, Chang Fang-Rong, Lin Chih-Yuan, Chou Chi-Jung, Chiu Hui-Fen, Wu Ming-Jung, Wu Yang-Chang
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China.
J Nat Prod. 2002 Apr;65(4):470-5. doi: 10.1021/np0105578.
Three new monotetrahydrofuran annonaceous acetogenins, muricin H (1), muricin I (2), and cis-annomontacin (3), along with five known acetogenins, annonacin, annonacinone, annomontacin, murisolin, and xylomaticin, were isolated from the seeds of Annona muricata. Additionally, two new monotetrahydrofuran annonaceous acetogenins, cis-corossolone (4) and annocatalin (5), together with four known ones, annonacin, annonacinone, solamin, and corossolone, were isolated from the leaves of this species. The structures of all new isolates were elucidated and characterized by spectral and chemical methods. These new acetogenins exhibited significant activity in in vitro cytotoxic assays against two human hepatoma cell lines, Hep G(2) and 2,2,15. Compound 5 showed a high selectivity toward the Hep 2,2,15 cell line.
从番荔枝种子中分离出三种新的单四氢呋喃类番荔枝乙酰精，即番荔枝辛 H（1）、番荔枝辛 I（2）和顺式番荔枝蒙他辛（3），以及五种已知的乙酰精，即番荔枝辛、番荔枝辛酮、番荔枝蒙他辛、番荔枝索林和木番荔枝素。此外，从该物种的叶子中分离出两种新的单四氢呋喃类番荔枝乙酰精，即顺式科罗索酮（4）和番荔枝催化素（5），以及四种已知的，即番荔枝辛、番荔枝辛酮、索拉明和科罗索酮。所有新分离物的结构均通过光谱和化学方法进行了阐明和表征。这些新的乙酰精在针对两种人肝癌细胞系Hep G(2)和2,2,15的体外细胞毒性试验中表现出显著活性。化合物5对Hep 2,2,15细胞系表现出高选择性。
