Rask-Andersen A, Boman J, Grängsjö A, Silverdal M, Lindberg M, Lundberg M, Svensson L
Department of Occupational and Environmental Medicine, University Hospital, Uppsala, Sweden.
Allergy. 2000 Sep;55(9):836-41. doi: 10.1034/j.1398-9995.2000.00484.x.
Cases of occupational asthma have been reported in condom factories in the UK and France, but there has been no epidemiologic study of groups of workers in such factories. This investigation aimed to study the prevalence of symptoms in a Swedish condom factory, to determine groups at special risk, and to suggest preventive measures.
A questionnaire was mailed to 35 employees, 29 women and six men with mean ages of 37 and 32 years, respectively. All subjects were interviewed by a physician and underwent skin prick test with latex and epicutaneous testing with 39 substances, and blood samples were taken for allergy testing.
Phadiatop was positive in 23%, RAST against Lycopodium in 31%, and RAST against latex in one of these 11. Ten subjects (29%) had work-related nose/eye symptoms; of these, eight had positive RAST to Lycopodium; three also had symptoms of occupational asthma and contact urticaria. Only one had positive RAST to latex. Five of the nine subjects with positive Phadiatop also had positive RAST to Lycopodium. All those with RAST positive to Lycopodium had worked in packaging, the area of the factory with the greatest exposure. The results of the patch tests did not correlate with the work-related symptoms.
In a Swedish condom factory, there were a high prevalence of rhinoconjunctivitis and a small number of cases of asthma and contact urticaria caused by allergy to Lycopodium.
英国和法国的避孕套工厂已报告有职业性哮喘病例,但尚未对这类工厂的工人群体进行流行病学研究。本调查旨在研究一家瑞典避孕套工厂的症状患病率,确定特殊风险群体,并提出预防措施。
向35名员工邮寄了问卷,其中29名女性和6名男性,平均年龄分别为37岁和32岁。所有受试者均接受医生访谈,并进行了乳胶皮肤点刺试验和39种物质的皮肤斑贴试验,同时采集血样进行过敏检测。
23%的受试者Phadiatop检测呈阳性,31%的受试者针对石松子的放射性过敏原吸附试验(RAST)呈阳性,在这11名受试者中有1名针对乳胶的RAST呈阳性。10名受试者(29%)有与工作相关的鼻/眼症状;其中,8名受试者针对石松子的RAST呈阳性;3名受试者还有职业性哮喘和接触性荨麻疹症状。只有1名受试者针对乳胶的RAST呈阳性。9名Phadiatop检测呈阳性的受试者中有5名针对石松子的RAST也呈阳性。所有针对石松子RAST呈阳性的受试者都在包装部门工作,该部门是工厂中接触最多的区域。斑贴试验结果与工作相关症状无关。
在一家瑞典避孕套工厂,鼻结膜炎患病率较高,有少数因对石松子过敏引起的哮喘和接触性荨麻疹病例。