Brady A F, Waters C S, Pocha M J, Brueton L A
Kennedy-Galton Centre, North West London Hospitals NHS Trust, Harrow, Middlesex, UK.
Clin Genet. 2000 Aug;58(2):142-6. doi: 10.1034/j.1399-0004.2000.580209.x.
We present a 3-year-old boy with constitutional partial trisomy 8 mosaicism (karyotype 47,XY, + del(8)(p12)/46,XY) who developed chronic myelomonocytic leukaemia and we review the few reported cases of constitutional trisomy 8 mosaicism (CT8M) associated with malignancy. This case highlights the association between CT8M and the development of malignancies, haematological malignancies in particular.
我们报告了一名患有先天性8号染色体嵌合型部分三体（核型47,XY, + del(8)(p12)/46,XY）的3岁男孩，他患上了慢性粒单核细胞白血病，并且我们回顾了少数几例与恶性肿瘤相关的先天性8号染色体嵌合型三体（CT8M）病例报告。该病例突出了CT8M与恶性肿瘤发生之间的关联，尤其是血液系统恶性肿瘤。
