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本文引用的文献

1
The mammalian HSF4 gene generates both an activator and a repressor of heat shock genes by alternative splicing.哺乳动物的HSF4基因通过可变剪接产生热休克基因的激活因子和抑制因子。
J Biol Chem. 1999 Sep 24;274(39):27845-56. doi: 10.1074/jbc.274.39.27845.
2
Molecular mechanisms controlling constitutive and IFN-gamma-inducible HLA-G expression in various cell types.控制不同细胞类型中组成型和IFN-γ诱导型HLA-G表达的分子机制。
J Reprod Immunol. 1999 Jul;43(2):213-24. doi: 10.1016/s0165-0378(99)00035-2.
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IL-10 selectively induces HLA-G expression in human trophoblasts and monocytes.
Int Immunol. 1999 May;11(5):803-11. doi: 10.1093/intimm/11.5.803.
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The functionality of HLA-G is emerging.
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Inhibitory receptors sensing HLA-G1 molecules in pregnancy: decidua-associated natural killer cells express LIR-1 and CD94/NKG2A and acquire p49, an HLA-G1-specific receptor.孕期感知HLA - G1分子的抑制性受体：蜕膜相关自然杀伤细胞表达LIR - 1和CD94/NKG2A并获得p49，一种HLA - G1特异性受体。
Proc Natl Acad Sci U S A. 1999 May 11;96(10):5674-9. doi: 10.1073/pnas.96.10.5674.
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Natural killer cells fertile with receptors for HLA-G?带有HLA - G受体的自然杀伤细胞是否具有繁殖能力？
Proc Natl Acad Sci U S A. 1999 May 11;96(10):5343-5. doi: 10.1073/pnas.96.10.5343.
7
Heterogeneity of HLA-G gene transcription and protein expression in malignant melanoma biopsies.恶性黑色素瘤活检中HLA - G基因转录和蛋白表达的异质性。
Cancer Res. 1999 Apr 15;59(8):1954-60.
8
Tetrameric complexes of human histocompatibility leukocyte antigen (HLA)-G bind to peripheral blood myelomonocytic cells.人类组织相容性白细胞抗原（HLA）-G的四聚体复合物与外周血髓单核细胞结合。
J Exp Med. 1999 Apr 5;189(7):1149-56. doi: 10.1084/jem.189.7.1149.
9
A human histocompatibility leukocyte antigen (HLA)-G-specific receptor expressed on all natural killer cells.一种在所有自然杀伤细胞上表达的人类组织相容性白细胞抗原（HLA）-G特异性受体。
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Interferons enhance HLA-G mRNA and protein in transfected mouse fibroblasts.
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热休克和亚砷酸盐可诱导肿瘤细胞系中非经典I类组织相容性HLA-G基因的表达。

Heat shock and arsenite induce expression of the nonclassical class I histocompatibility HLA-G gene in tumor cell lines.

作者信息

Ibrahim E C, Morange M, Dausset J, Carosella E D, Paul P

机构信息

CEA, Service de Recherches en Hémato-Immunologie, DSV/DRM, Hôpital Saint-Louis, Centre Hayem, Paris, France.

出版信息

Cell Stress Chaperones. 2000 Jul;5(3):207-18. doi: 10.1379/1466-1268(2000)005<0207:hsaaie>2.0.co;2.

DOI:10.1379/1466-1268(2000)005<0207:hsaaie>2.0.co;2
PMID:11005379
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC312887/
Abstract

The nonclassical histocompatibility class I gene HLA-G has a tissue-restricted expression. To explore mechanisms involved in HLA-G transcriptional regulation, we have investigated the effect of stress, including heat shock and arsenite treatment, on HLA-G expression in tumor cell lines. We show that stress induces an increase of the level of the different HLA-G alternative transcripts without affecting other MHC class I HLA-A, -B, -E, and -F transcripts. A heat shock element (HSE) that binds to heat shock factor 1 (HSF1) on stress conditions was further identified within the HLA-G promoter. Considering the ability of HLA-G to modulate the function of immunocompetent cells, we hypothesize a new feature of HLA-G as a signal regulating the immune response to stress.

摘要

非经典组织相容性I类基因HLA-G具有组织限制性表达。为了探究参与HLA-G转录调控的机制，我们研究了应激（包括热休克和亚砷酸盐处理）对肿瘤细胞系中HLA-G表达的影响。我们发现应激可诱导不同HLA-G可变转录本水平升高，而不影响其他MHC I类基因HLA-A、-B、-E和-F的转录本。在HLA-G启动子内进一步鉴定出一个在应激条件下与热休克因子1（HSF1）结合的热休克元件（HSE）。鉴于HLA-G具有调节免疫活性细胞功能的能力，我们推测HLA-G具有作为调节对应激免疫反应的信号的新特性。