封闭鸡群中三个品系鸡对鸡传染性贫血病毒的体液免疫反应
Humoral immune responses to chicken infectious anemia virus in three strains of chickens in a closed flock.
作者信息
Cardona C, Lucio B, O'Connell P, Jagne J, Schat K A
机构信息
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
出版信息
Avian Dis. 2000 Jul-Sep;44(3):661-7.
This is a comparative study on seroconversion to chicken infectious anemia virus (CIAV) in a closed flock of specific-pathogen-free chickens undergoing a natural outbreak and after vaccination of some of these flocks with a commercial, live vaccine. The N2a strain (B21B21 haplotype) had the highest seroconversion after natural infection (94%) or vaccination (100%), followed by the P2a strain (B19B19) at 75%-82% seroconversion after natural infection and 85% seroconversion after vaccination. The S13 (B13B13) chickens were 26% seropositive after natural infection and 75% seropositive after vaccination. N2a chickens with polymerase chain reaction (PCR)-positive tissues were 97% seropositive compared to 80%-83% PCR-positive and seropositive for the P2a chickens and only 8% seropositive and PCR-positive for the S13 chickens. Seroconversion occurred at or near sexual maturity after natural infection in seven flocks studied.
这是一项关于在一群经历自然暴发的无特定病原体鸡群以及其中部分鸡群接种商业活疫苗后，鸡传染性贫血病毒（CIAV）血清转化情况的比较研究。N2a毒株（B21B21单倍型）在自然感染后血清转化率最高（94%），接种疫苗后血清转化率为100%，其次是P2a毒株（B19B19），自然感染后血清转化率为75%-82%，接种疫苗后血清转化率为85%。S13（B13B13）鸡在自然感染后血清阳性率为26%，接种疫苗后血清阳性率为75%。聚合酶链反应（PCR）检测组织呈阳性的N2a鸡血清阳性率为97%，相比之下，P2a鸡PCR检测呈阳性且血清阳性的比例为80%-83%，而S13鸡PCR检测呈阳性且血清阳性的比例仅为8%。在所研究的七个鸡群中，自然感染后血清转化发生在性成熟时或接近性成熟时。
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