Johnson J G, Cohen P, Brook J S
Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY, USA.
Am J Psychiatry. 2000 Oct;157(10):1679-81. doi: 10.1176/appi.ajp.157.10.1679.
The study investigated cross-sectional and longitudinal associations between bipolar disorder and other psychiatric disorders during adolescence and early adulthood.
Psychiatric interviews were administered to a representative community sample of 717 youths and their mothers in 1983 (mean age of youths=14 years) and again in 1985-1986, and 1991-1993.
A wide range of psychiatric disorders co-occurred with bipolar disorder during adolescence and early adulthood. Adolescent anxiety disorders were uniquely associated with increased risk for early adulthood bipolar disorder after adolescent bipolar disorder was accounted for. Manic symptoms during adolescence were associated with increased risk for anxiety and depressive disorders during early adulthood after adolescent anxiety and depressive disorders were accounted for.
Adolescents with anxiety disorders may be at increased risk for bipolar disorder or clinically significant manic symptoms during early adulthood. Adolescents with manic symptoms may be at increased risk for anxiety and depressive disorders during early adulthood.
本研究调查了青少年期和成年早期双相情感障碍与其他精神障碍之间的横断面和纵向关联。
1983年（青少年平均年龄 = 14岁）对717名青少年及其母亲组成的具有代表性的社区样本进行了精神病学访谈，并于1985 - 1986年以及1991 - 1993年再次进行访谈。
在青少年期和成年早期，多种精神障碍与双相情感障碍共病。在排除青少年双相情感障碍后，青少年焦虑症与成年早期双相情感障碍风险增加存在独特关联。在排除青少年焦虑症和抑郁症后，青少年期的躁狂症状与成年早期焦虑症和抑郁症风险增加有关。
患有焦虑症的青少年在成年早期患双相情感障碍或出现具有临床意义的躁狂症状的风险可能增加。有躁狂症状的青少年在成年早期患焦虑症和抑郁症的风险可能增加。
