在暴露于氨基酸类似物的大肠杆菌中合成的MS2蛋白的命运。
Fate of MS2 proteins synthesized in Escherichia coli exposed to amino acid analogues.
作者信息
Prouty W F
出版信息
J Virol. 1975 Oct;16(4):1090-3. doi: 10.1128/JVI.16.4.1090-1093.1975.
Abstract
Incorporation of an analoque into MS2 coded proteins prevents the maturation of phages. In addition, there is an alteration in the relative amount of coat protein to replicase protein synthesized, which supports the hypothesis that normal coat protein serves a physiological role as a translation repressor. Further, abnormal proteins, synthesized from the phage genome, are degraded, presumably by a host catabolic system, more rapidly than the normal gene products.
摘要
将类似物掺入MS2编码的蛋白质中会阻止噬菌体的成熟。此外，合成的外壳蛋白与复制酶蛋白的相对量发生了改变，这支持了正常外壳蛋白作为翻译阻遏物发挥生理作用的假说。此外，由噬菌体基因组合成的异常蛋白质可能会被宿主分解代谢系统更快地降解，其速度比正常基因产物更快。
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