Kurohara S S, Di Saia P, Kurohara J, Grossman I, George F W, Morrow C P
AJR Am J Roentgenol. 1979 Aug;133(2):293-7. doi: 10.2214/ajr.133.2.293.
Results were evaluated for 651 consecutive patients with invasive cancer of the intact uterine cervix. From 1963 through 1967 319 patients were treated primarily with the older Los Angeles County Hospital system of orthovoltage radiation and intracavitary radium therapy. Thereafter, 1968--1974, 332 patients were treated primarily with a newer modified M. D. Anderson Tumor Institute system of megavoltage radiation and afterloading intracavitary radium therapy. Age distribution and histology were similar for both groups, but clinical stage was slightly more advanced for patients treated earlier. Crude and net 5 year survival rates were 36% and 49% for the early group and 54% and 67% for the later group. Net 5 year survival rates for the earlier group by stage were: stage I, 74%; II, 62%; III, 23%; and IV, 6%. Survival rates for the later group were: I, 81%; II 76%; III, 50%; and IV, 15%. We believe this improvement can be attributed to more effective intracavitary radium therapy for handling local cancer and to delivery of cancericidal doses of radiation to regional nodes with the megavoltage radiation apparatus, as well as to the greater cooperative efforts put forth in the management of County Hospital patients.
对651例连续性完整子宫颈浸润癌患者的治疗结果进行了评估。1963年至1967年期间，319例患者主要采用洛杉矶县医院旧的深部X线放射治疗和腔内镭疗系统进行治疗。此后，在1968年至1974年期间，332例患者主要采用更新的、改良的MD安德森肿瘤研究所的兆伏级放射治疗和后装腔内镭疗系统进行治疗。两组患者的年龄分布和组织学情况相似，但早期接受治疗的患者临床分期略晚。早期组的5年粗生存率和净生存率分别为36%和49%，后期组分别为54%和67%。早期组按分期的5年净生存率为：I期，74%；II期，62%；III期，23%；IV期，6%。后期组的生存率为：I期，81%；II期，76%；III期，50%；IV期，15%。我们认为，这种改善可归因于采用更有效的腔内镭疗来处理局部癌症，以及使用兆伏级放射治疗设备向区域淋巴结输送具有抗癌剂量的辐射，同时也归因于在县医院患者管理中付出的更大协作努力。
