Katz A I, Emmanouel D S, Lindheimer M D
Nephron. 1975;15(3-5):223-49. doi: 10.1159/000180514.
Thyroid hormones affect both renal morphology and function. They are required for kidney growth and development, and thyroid deficiency results in decreased renal plasma flow and glomerular filtration rate and in impaired urinary concentration and dilution. Thyroid hormones also influence membrane transport and electrolyte metabolism, and alterations in mineral metabolism in hyperthyroidism frequently cause calcium nephropathy which affects renal function adversely. The kidney plays an important role in the peripheral metabolism of iodine and thyroid hormones, and thyroid function is altered in certain kidney diseases, particularly chronic renal failure. The pathogenesis of these alterations is currently under active investigation.
甲状腺激素影响肾脏的形态和功能。它们是肾脏生长和发育所必需的，甲状腺功能减退会导致肾血浆流量和肾小球滤过率降低，以及尿液浓缩和稀释功能受损。甲状腺激素还影响膜转运和电解质代谢，甲状腺功能亢进时矿物质代谢的改变常导致钙肾病，对肾功能产生不利影响。肾脏在碘和甲状腺激素的外周代谢中起重要作用，在某些肾脏疾病，特别是慢性肾衰竭中，甲状腺功能会发生改变。目前正在积极研究这些改变的发病机制。
