Department of Medicine, Xi'an Jiaotong University Health Science Center, Xi'an 710061, Shaanxi Province, PR China.
Department of Medicine, Honghui Hospital, Xi'an Jiaotong University, Xi'an, 710054, China.
Endocr Metab Immune Disord Drug Targets. 2024;24(11):1323-1334. doi: 10.2174/0118715303268738231129093935.
Kidney stones and thyroid disease are two common diseases in the general population, with multiple common risk factors. The associations between kidney stones and thyroid disease are unclear.
This study aims to assess the association between 'once had a thyroid disease' and the odds of kidney stones.
Adult participants from the National Health and Nutrition Examination Survey (NHANES) 2007-2018 with reliable kidney stone and thyroid disease data were included. Adjusting for age, gender, race, education level, and marital status, diabetes, hypertension, gout, angina pectoris, stroke, and asthma, logistic regression was used to examine the relationship between kidney stones and thyroid illness.
Using stratified analysis, the association between thyroid illness and kidney stones was investigated further. Among the participants, 4.9% had kidney stones, and 10.1% had thyroid disease. Kidney stone was associated with thyroid disease (OR=1.441, (95% CI:1.294-1.604), p <0.01), which remained significant (OR=1.166, (95% CI:1.041-1.305), p <0.01) after adjustments with age, gender, race, education level and marital status, diabetes, hypertension, gout, angina pectoris, stroke, and asthma. Stratified by blood lead, blood cadmium, and blood urea nitrogen levels in the human body, the odds of kidney stones still increased with once having a previous thyroid disease.
In this large nationally representative survey over 10 years, kidney stone was strongly associated with thyroid disease. In this cross-sectional study, we explored the association between thyroid disease and kidney stones, which may help clinicians intervene in them early.
肾结石和甲状腺疾病是普通人群中两种常见的疾病，具有多种共同的危险因素。肾结石和甲状腺疾病之间的关联尚不清楚。
本研究旨在评估“曾患有甲状腺疾病”与肾结石发病几率之间的关系。
本研究纳入了来自 2007-2018 年全国健康和营养调查（NHANES）的成年参与者，这些参与者具有可靠的肾结石和甲状腺疾病数据。通过调整年龄、性别、种族、教育程度和婚姻状况、糖尿病、高血压、痛风、心绞痛、中风和哮喘等因素，使用逻辑回归分析了肾结石与甲状腺疾病之间的关系。
通过分层分析，进一步研究了甲状腺疾病与肾结石之间的关系。在参与者中，4.9%患有肾结石，10.1%患有甲状腺疾病。肾结石与甲状腺疾病相关（OR=1.441，95%CI：1.294-1.604，p<0.01），在调整年龄、性别、种族、教育程度和婚姻状况、糖尿病、高血压、痛风、心绞痛、中风和哮喘等因素后，这种相关性仍然显著（OR=1.166，95%CI：1.041-1.305，p<0.01）。分层分析人体血液铅、镉和尿素氮水平后，曾患有甲状腺疾病的患者肾结石发病几率仍有所增加。
在这项超过 10 年的大型全国代表性调查中，肾结石与甲状腺疾病密切相关。在这项横断面研究中，我们探讨了甲状腺疾病与肾结石之间的关系，这可能有助于临床医生早期进行干预。
