van de Kamp M, Schuurs T A, Vos A, van der Lende T R, Konings W N, Driessen A J
Department of Molecular Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, 9750 AA Haren, The Netherlands.
Appl Environ Microbiol. 2000 Oct;66(10):4536-8. doi: 10.1128/AEM.66.10.4536-4538.2000.
Penicillium chrysogenum uses sulfate as a source of sulfur for the biosynthesis of penicillin. Sulfate uptake and the mRNA levels of the sulfate transporter-encoding sutB and sutA genes are all reduced by high sulfate concentrations and are elevated by sulfate starvation. In a high-penicillin-yielding strain, sutB is effectively transcribed even in the presence of excess sulfate. This deregulation may facilitate the efficient incorporation of sulfur into cysteine and penicillin.
产黄青霉利用硫酸盐作为青霉素生物合成的硫源。高硫酸盐浓度会降低硫酸盐的摄取以及编码硫酸盐转运蛋白的sutB和sutA基因的mRNA水平，而硫酸盐饥饿会使其升高。在高产青霉素菌株中，即使存在过量硫酸盐，sutB仍能有效转录。这种去调控可能有助于将硫高效掺入半胱氨酸和青霉素中。
