Veenstra A E, van Solingen P, Bovenberg R A, van der Voort L H
Gist-brocades Research and Development, Delft, The Netherlands.
J Biotechnol. 1991 Jan;17(1):81-90. doi: 10.1016/0168-1656(91)90028-t.
The penDE gene from Penicillium chrysogenum has been isolated; the gene is located in close vicinity of the pcbC gene. Amplification of the pcbC-penDE gene cluster in Penicillium chrysogenum Wis54-1255 leads to a significant increase in penicillin production. In selected transformants an increase of up to 40% is observed.
产黄青霉的penDE基因已被分离出来；该基因位于pcbC基因附近。在产黄青霉Wis54-1255中扩增pcbC-penDE基因簇可使青霉素产量显著增加。在选定的转化体中观察到产量增加高达40%。
