Gottschalk L A, Bechtel R J, Maguire G A, Harrington D E, Levinson D M, Franklin D L, Carcamo D
Department of Psychiatry and Human Behavior, University of California, Irvine Medical Center, Orange, USA.
Compr Psychiatry. 2000 Sep-Oct;41(5):326-33. doi: 10.1053/comp.2000.9015.
This study aimed to cross-validate the capacity of a computer software program to detect and measure, using a measurement method applied to the content and form analysis of 5-minute speech samples, cognitive impairment and associated comorbid neuropsychiatric psychobiological dimensions in drug-abusing patients. At the University of California-Irvine (UCI) Neuropsychiatric Center, 28 drug-abusing inpatients using illegal drugs were clinically evaluated. Their scores for cognitive impairment derived by the computerized content analysis method were compared with scores derived from selected tests from the Halstead-Reitan Neuropsychological Test Battery, the computerized Automated Neuropsychological Assessment Metric Battery (ANAM), the Alzheimer's Disease Assessment Scale-Cognitive Portion, the Stroop Color and Word Test, the Symbol Digit Modalities Test, and the Controlled Oral Word Association Test. The statistical significance (P value) of the correlations of scores from these different measures with scores obtained from the computerized content analysis measures was less than .05 to .001. The comparative "hit rate," detecting cognitive impairment above the norms for each measure administered to these drug-abusing patients, for the computerized content analysis measures and some of the ANAM neuropsychological measures was 75% to 89%, and for the other neuropsychological measures, 25% to 64%. In conclusion, the computerized content analysis methodology applied to 5-minute verbal samples is a valid, rapid, easily administered measurement instrument for assessing the magnitude of cognitive impairment and comorbid neuropsychiatric dimensions.
本研究旨在通过一种应用于5分钟言语样本内容和形式分析的测量方法，交叉验证计算机软件程序检测和测量药物滥用患者认知障碍及相关共病神经精神心理生物学维度的能力。在加利福尼亚大学欧文分校（UCI）神经精神病中心，对28名使用非法药物的药物滥用住院患者进行了临床评估。将通过计算机化内容分析方法得出的他们的认知障碍评分，与从哈尔斯特德-雷顿神经心理测试电池、计算机化自动神经心理评估量表电池（ANAM）、阿尔茨海默病评估量表-认知部分、斯特鲁普颜色和文字测试、符号数字模态测试以及受控口语单词联想测试中选取的测试得出的评分进行比较。这些不同测量方法的评分与计算机化内容分析测量方法获得的评分之间相关性的统计学显著性（P值）小于0.05至0.001。对于这些药物滥用患者所进行的各项测量，计算机化内容分析测量方法和部分ANAM神经心理测量方法检测高于正常标准的认知障碍的比较“命中率”为75%至89%，而其他神经心理测量方法的“命中率”为25%至64%。总之，应用于5分钟言语样本的计算机化内容分析方法是一种有效、快速且易于实施的测量工具，可用于评估认知障碍的程度和共病神经精神维度。
