碳水化合物调控的DNA光裂解：新型糖基蒽醌的设计、合成与评估
Carbohydrate-modulated DNA photocleavage: design, synthesis, and evaluation of novel glycosyl anthraquinones.
作者信息
Toshima K, Maeda Y, Ouchi H, Asai A, Matsumura S
机构信息
Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan.
出版信息
Bioorg Med Chem Lett. 2000 Oct 2;10(19):2163-5. doi: 10.1016/s0960-894x(00)00410-8.
Abstract
Novel and artificial anthraquinone-carbohydrate hybrids were designed and synthesized, and found to effectively cleave DNA under irradiation with a long wavelength UV light and also exhibit cytotoxicity against HeLa S3 cells.
摘要
设计并合成了新型人工蒽醌-碳水化合物杂化物，发现其在长波长紫外光照射下能有效切割DNA，并且对HeLa S3细胞具有细胞毒性。
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