β-咔啉-碳水化合物杂化物：新型DNA光裂解剂的分子设计、化学合成与评价
Beta-carboline-carbohydrate hybrids: molecular design, chemical synthesis and evaluation of novel DNA photocleavers.
作者信息
Toshima Kazunobu, Okuno Yukiko, Nakajima Yoko, Matsumura Shuichi
机构信息
Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, 223-8522, Yokohama, Japan.
出版信息
Bioorg Med Chem Lett. 2002 Feb 25;12(4):671-3. doi: 10.1016/s0960-894x(01)00828-9.
Abstract
Beta-carboline present in beta-carboline alkaloids from marine organisms was found, for the first time, to cleave DNA at the guanine site upon irradiation with UV light with a long wavelength without any additive, and beta-carboline-carbohydrate hybrid system was effective for DNA cleavage.
摘要
首次发现，海洋生物中β-咔啉生物碱所含的β-咔啉在无任何添加剂的情况下，经长波长紫外光照射后能在鸟嘌呤位点切割DNA，且β-咔啉-碳水化合物杂合体系对DNA切割有效。
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