de Weert K, Traksel M, Gielen M, Slappendel R, Weber E, Dirksen R
Institute for Anaesthesiology, University Hospital Nijmegen, Post-box 9101, Geert Grooteplein 18, 6500 HB Nijmegen, The Netherlands.
Anaesthesia. 2000 Oct;55(10):1020-4. doi: 10.1046/j.1365-2044.2000.01618-4.x.
The purpose of this double-blind study was to investigate the incidence of transient neurological symptoms after the use of isobaric lidocaine and isobaric prilocaine for spinal anaesthesia. Seventy patients (ASA 1-2, age between 18 and 70 years) were randomly assigned to two groups of 35 patients each, to receive either isobaric 2% lidocaine 4 ml or isobaric 2% prilocaine 4 ml intrathecally, at the L3-4 interspace. One patient in the prilocaine group could not be included because data were incomplete. On the first postoperative day, patients were evaluated for transient neurological symptoms. Pain was scored on a 10-point scale. Seven patients (20%) in the lidocaine group had transient neurological symptoms with a mean pain score of 5.3, whereas no patient in the prilocaine group had these complaints (p = 0.006). Symptoms disappeared within 4 days. Prilocaine results in a lower incidence of transient neurological symptoms than lidocaine intrathecally and therefore it is more suitable for short surgical procedures.
这项双盲研究的目的是调查等比重利多卡因和等比重丙胺卡因用于脊髓麻醉后短暂性神经症状的发生率。70例患者（ASA 1-2级，年龄18至70岁）被随机分为两组，每组35例，分别在L3-4间隙鞘内注射4毫升等比重2%利多卡因或4毫升等比重2%丙胺卡因。丙胺卡因组有1例患者因数据不完整未纳入研究。术后第一天，对患者进行短暂性神经症状评估。疼痛采用10分制评分。利多卡因组有7例患者（20%）出现短暂性神经症状，平均疼痛评分为5.3分，而丙胺卡因组无患者出现这些症状（p = 0.006）。症状在4天内消失。鞘内注射丙胺卡因导致短暂性神经症状的发生率低于利多卡因，因此更适合短时间的外科手术。
