Horie Y, Kato M
Department of Pathology, Tottori University Hospital, Yonago, Japan.
Pathol Int. 2000 Sep;50(9):754-8. doi: 10.1046/j.1440-1827.2000.01102.x.
A case of testicular yolk sac tumor (endodermal sinus tumor) consisting predominantly of hepatoid cells is documented. A mass measuring approximately 4 x 3 cm was noted in the left testis of a 64-year-old man. Preoperative examination revealed an elevated serum level of alpha-fetoprotein (5479 ng/mL). Histologically, the lesion was composed predominantly of sheet-like or trabecular proliferation of hepatocyte-like cells with eosinophilic or clear cytoplasm. The tumor cells were immunoreactive for alpha-fetoprotein, antimitochondrial antibody, cytokeratin (AE1/AE3), alpha-1-antichymotrypsin, alpha-1-antitrypsin, albumin, carcinoembryonic antigen and epithelial membrane antigen. It was necessary to distinguish this variant lesion from metastatic hepatocellular carcinoma, embryonal carcinoma and hepatoid carcinoma.
本文记录了一例主要由肝样细胞组成的睾丸卵黄囊瘤（内胚窦瘤）。在一名64岁男性的左侧睾丸中发现了一个大小约为4×3 cm的肿块。术前检查显示血清甲胎蛋白水平升高（5479 ng/mL）。组织学上，病变主要由具有嗜酸性或透明细胞质的肝细胞样细胞呈片状或小梁状增生组成。肿瘤细胞对甲胎蛋白、抗线粒体抗体、细胞角蛋白（AE1/AE3）、α-1-抗糜蛋白酶、α-1-抗胰蛋白酶、白蛋白、癌胚抗原和上皮膜抗原呈免疫反应性。有必要将这种变异病变与转移性肝细胞癌、胚胎癌和肝样癌区分开来。
