Hirsch V M, Lifson J D
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Rockville, Maryland 20852, USA.
Adv Pharmacol. 2000;49:437-77. doi: 10.1016/s1054-3589(00)49034-4.
As presented in this review, there are a number of different models of both natural and experimental infection of monkeys with primate lentiviruses. There are numerous different viruses and multiple different monkey species, making for a potentially large number of different combinations. The fact that each different combination of virus isolate and host macaque species may show different behavior underscores the need to understand the different models and their key features. On the one hand, this diversity of systems underscores the need to provide some standardization of the systems used for certain kinds of studies, such as vaccine evaluations, in order to facilitate the comparison of results obtained in different experiments, but in essentially the same experimental system. On the other hand, the rich diversity of different systems, with different features and behaviors, represents a tremendous resource, among other things allowing the investigator to select the system that best recapitulates particular aspects of human HIV infection for study in a relevant nonhuman primate model. Such studies have provided, and may be expected to continue to provide, important insights to guide HIV treatment and vaccine development in the future.
如本综述所述，存在多种猴子自然感染和实验感染灵长类慢病毒的不同模型。有众多不同的病毒和多种不同的猴子物种，这就产生了大量潜在的不同组合。病毒分离株与宿主猕猴物种的每种不同组合可能表现出不同行为，这一事实凸显了了解不同模型及其关键特征的必要性。一方面，系统的这种多样性强调了对用于某些类型研究（如疫苗评估）的系统进行标准化的必要性，以便于比较在不同实验中但基本相同的实验系统中获得的结果。另一方面，具有不同特征和行为的不同系统的丰富多样性代表了巨大的资源，除其他外，使研究人员能够选择最能在相关非人灵长类动物模型中重现人类HIV感染特定方面的系统进行研究。此类研究已经为未来指导HIV治疗和疫苗开发提供了重要见解，并且有望继续提供此类见解。
