Hanzlick R L, Senhauser D A
Am J Clin Pathol. 1979 Jul;72(1):76-9. doi: 10.1093/ajcp/72.1.76.
A case of subclinical hemolytic disease of the newborn resulting in reticulocytosis and positive direct and indirect antiglobulin tests in an infant both ABO- and Rh(D)-compatible with its mother is reported. The antibody was an IgG, non-complement-binding molecule present in low titer with a low avidity for the antigen, acted optimally in enzyme systems, did not manifest dosage effect, and caused slight extravascular destruction of fetal erythrocytes. Routine antibody screening of all pregnant women should be performed and neonatal cord blood specimens analyzed to avoid unexpected infant morbidity and mortality, and to characterize hemolytic disease of the newborn due to rare atypical antibodies more fully.
本文报告了一例新生儿亚临床溶血病病例，该病例导致婴儿出现网织红细胞增多症，直接和间接抗球蛋白试验呈阳性，婴儿与母亲的ABO血型和Rh（D）血型均相容。该抗体为IgG，是一种非补体结合分子，效价低，与抗原的亲和力低，在酶系统中作用最佳，不表现剂量效应，并导致胎儿红细胞轻微血管外破坏。应对所有孕妇进行常规抗体筛查，并对新生儿脐带血标本进行分析，以避免意外的婴儿发病和死亡，并更全面地鉴定由罕见非典型抗体引起的新生儿溶血病。
