Schneider C, Bohnenstengel F I, Nugroho B W, Wray V, Witte L, Hung P D, Kiet L C, Proksch P
Institut für Phamazeutische Biologie, Heinrich Heine Universität Düsseldorf Germany.
Phytochemistry. 2000 Aug;54(8):731-6. doi: 10.1016/s0031-9422(00)00205-3.
Bark of Aglaia spectabilis collected on the island of Phu Quoc (Vietnam) yielded insecticidal cyclopentatetrahydrobenzofurans of the rocaglamide type including four new natural products. Structure elucidation of the new compounds is described. All rocaglamide derivatives isolated exhibited strong insecticidal activity towards neonate larvae of the polyphagous pest insect Spodoptera littoralis when incorporated into an artificial diet. LC50 values varied from 0.8 to 80 ppm. The most active compounds isolated, methylrocaglate and C-3' hydroxylmethylrocaglate, were similar with regard to their insecticidal activity to the well-known natural insecticide azadirachtin.
在富国岛（越南）采集的米仔兰树皮中分离得到了具有杀虫活性的罗卡酰胺类环戊四氢苯并呋喃化合物，其中包括四种新的天然产物。文中描述了这些新化合物的结构解析过程。所有分离得到的罗卡酰胺衍生物在添加到人工饲料中时，对多食性害虫斜纹夜蛾的初孵幼虫均表现出较强的杀虫活性。其半数致死浓度（LC50）值在0.8至80 ppm之间。所分离得到的活性最强的化合物，即甲基罗卡酯和C-3'羟甲基罗卡酯，在杀虫活性方面与著名的天然杀虫剂印楝素相似。
