Grege H, Pache T, Brem B, Bacher M, Hofer O
Comparative and Ecological Phytochemistry Department, Institute of Botany, University of Vienna, Wein, Austria.
Phytochemistry. 2001 May;57(1):57-64. doi: 10.1016/s0031-9422(00)00471-4.
Bioassays with lipophilic crude extracts of four Fijian Aglaia species against Spodoptera littoralis displayed strong insecticidal activity for A. basiphylla and A. gracilis, whereas A. archboldiana and A. vitiensis did not have any significant effects. The insect toxicity of A. basiphylla was caused by the well known benzofuran flavaglines rocaglamide, desmethylrocaglamide and aglafoline. In contrast, A. gracilis contained four related pyrimidinone derivatives in the root and stem bark, including two new congeners named marikarin and 3'-hydroxymarikarin. Moreover, two new putrescine bisamides, secoodorine and secopiriferine, a new benzopyran flavagline. desacetylaglain A. and a new norsesquiterpene were isolated from the leaves together with three known bisamides and 3-hydroxy-5,7,4'-trimethoxyflavone. The structures of the new compounds were elucidated by spectroscopic methods. Comparative feeding assays within the active pyrimidinone flavaglines showed that the free hydroxy group in aromatic ring A of marikarin diminishes insecticidal activity.
对四种斐济米仔兰属植物的亲脂性粗提物针对斜纹夜蛾进行的生物测定显示，基叶米仔兰和细米仔兰具有很强的杀虫活性，而阿奇博尔德米仔兰和维提岛米仔兰则没有任何显著效果。基叶米仔兰的昆虫毒性是由众所周知的苯并呋喃类黄酮罗卡酰胺、去甲基罗卡酰胺和米仔兰碱引起的。相比之下，细米仔兰的根和茎皮中含有四种相关的嘧啶酮衍生物，包括两种名为马里卡林和3'-羟基马里卡林的新同系物。此外，从叶中分离出两种新的腐胺双酰胺，即西科多林和西科皮里费林、一种新的苯并吡喃类黄酮、去乙酰米仔兰A和一种新的降倍半萜，以及三种已知的双酰胺和3-羟基-5,7,4'-三甲氧基黄酮。通过光谱方法阐明了新化合物的结构。在活性嘧啶酮类黄酮内进行的比较喂食试验表明，马里卡林芳环A中的游离羟基会降低杀虫活性。
