血清可溶性肿瘤坏死因子受体II（sTNF-R75）水平显然是单核细胞相关总体感染和炎症活动的一个指标。

Serum level of soluble tumor necrosis factor receptor II (sTNF-R75) is apparently an index of overall monocyte-related infectious and inflammatory activity.

作者信息

Huang Z S, Chiang B L, Hsu K L

机构信息

Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Republic of China.

出版信息

Am J Med Sci. 2000 Sep;320(3):183-7. doi: 10.1097/00000441-200009000-00009.

DOI:10.1097/00000441-200009000-00009

PMID:11014372

Abstract

BACKGROUND

The serum level of soluble tumor necrosis factor receptor II (sTNF-R75) has been recently found to correlate with the activity and/or severity of several different infectious and inflammatory diseases. These results have led us to presume that the serum sTNF-R75 level reflects the active immune activity of all causes and may correlate well with nonspecific infectious and inflammatory markers such as peripheral leukocyte counts and serum C-reactive protein level.

METHODS

In total, 110 apparently healthy adults, 55 men and 55 women, were enrolled in the study. Serum levels of sTNF-R75, C-reactive protein, globulin, alkaline phosphatase, lactate dehydrogenase, creatinine, urea nitrogen, and counts of neutrophils, lymphocytes, monocytes, eosinophils, and basophils were checked. The relationships between the serum sTNF-R75 level and other parameters were analyzed using the SAS statistical program.

RESULTS

By various statistical methods, the serum sTNF-R75 level showed consistently significant positive links with peripheral monocyte count, serum C-reactive protein level, and two parameters of renal clearance function (serum urea nitrogen and creatinine levels). Serum levels of alkaline phosphatase and lactate dehydrogenase had significant positive links with the serum sTNF-R75 level by multivariate regression analysis. There was no significant link between the serum sTNF-R75 level and counts of neutrophils, lymphocytes, eosinophils, or basophils.

CONCLUSIONS

Our results, together with those of recent reports showing positive correlations between the serum sTNF-R75 level and activities/severities of different infectious and inflammatory diseases, and also that TNF-alpha is principally produced by monocytes and macrophages, suggest that the serum sTNF-R75 level is very probably an index of overall monocyte-related infectious and inflammatory activities.

摘要

背景

最近发现可溶性肿瘤坏死因子受体II（sTNF-R75）的血清水平与几种不同的感染性和炎症性疾病的活动度和/或严重程度相关。这些结果使我们推测血清sTNF-R75水平反映了所有病因的活跃免疫活动，并且可能与非特异性感染和炎症标志物如外周血白细胞计数和血清C反应蛋白水平密切相关。

方法

总共110名表面健康的成年人（55名男性和55名女性）参与了本研究。检测了血清sTNF-R75、C反应蛋白、球蛋白、碱性磷酸酶、乳酸脱氢酶、肌酐、尿素氮水平以及中性粒细胞、淋巴细胞、单核细胞、嗜酸性粒细胞和嗜碱性粒细胞计数。使用SAS统计程序分析血清sTNF-R75水平与其他参数之间的关系。

结果

通过各种统计方法，血清sTNF-R75水平与外周血单核细胞计数、血清C反应蛋白水平以及两个肾清除功能参数（血清尿素氮和肌酐水平）始终呈现出显著的正相关。通过多变量回归分析，碱性磷酸酶和乳酸脱氢酶的血清水平与血清sTNF-R75水平呈现出显著的正相关。血清sTNF-R75水平与中性粒细胞、淋巴细胞、嗜酸性粒细胞或嗜碱性粒细胞计数之间没有显著相关性。