Sohal V S, Hasselmo M E
Department of Psychology, Harvard University, Cambridge, MA 02138, USA.
Network. 2000 Aug;11(3):169-90.
Neurons in inferior temporal (IT) cortex exhibit selectivity for complex visual stimuli and can maintain activity during the delay following the presentation of a stimulus in delayed match to sample tasks. Experimental work in awake monkeys has shown that the responses of IT neurons decline during presentation of stimuli which have been seen recently (within the past few seconds). In addition, experiments have found that the responses of IT neurons to visual stimuli also decline as the stimuli become familiar, independent of recency. Here a biologically based neural network simulation is used to model these effects primarily through two processes. The recency effects are caused by adaptation due to a calcium-dependent potassium current, and the familiarity effects are caused by competitive self-organization of modifiable feedforward synapses terminating on IT cortex neurons.
颞下（IT）皮质中的神经元对复杂视觉刺激表现出选择性，并且在延迟匹配样本任务中刺激呈现后的延迟期间能够保持活动。在清醒猴子身上进行的实验工作表明，IT神经元的反应在最近（过去几秒钟内）看到的刺激呈现期间会下降。此外，实验发现，IT神经元对视觉刺激的反应也会随着刺激变得熟悉而下降，与近期性无关。在此，基于生物学的神经网络模拟主要通过两个过程来模拟这些效应。近期效应是由钙依赖性钾电流引起的适应导致的，而熟悉效应是由终止于IT皮质神经元的可修改前馈突触的竞争性自组织引起的。
