Witte D A, Chen I, Brady J, Ramzy I, Truong L D, Ostrowski M L
Department of Pathology, Baylor College of Medicine, Houston, Texas, USA.
Acta Cytol. 2000 Sep-Oct;44(5):815-8. doi: 10.1159/000328567.
Osteomyelitis due to Cryptococcus neoformans typically exhibits lytic lesions on radiographs. Extensive periosteal reaction is an uncommon feature.
A 68-year-old man presented with pain and swelling in the left elbow. Radiologic studies exhibited a lytic humeral lesion with extensive periosteal reaction, interpreted as a malignant neoplasm. Fine needle aspiration biopsy (FNA) revealed abundant cryptococcal organisms.
Cryptococcus is an uncommon cause of lytic osseous lesions that may mimic malignant neoplasms. Extensive periosteal reaction may support a radiologic diagnosis of primary osseous malignancy in rare cases. FNA with examination of Diff-Quik-stained slides may be employed for distinguishing cryptococcal osteomyelitis from malignant tumors and for prompt identification of the organisms.
新型隐球菌引起的骨髓炎在X线片上通常表现为溶骨性病变。广泛的骨膜反应是一种不常见的特征。
一名68岁男性因左肘部疼痛和肿胀就诊。放射学检查显示肱骨有溶骨性病变并伴有广泛的骨膜反应，被解释为恶性肿瘤。细针穿刺活检（FNA）发现大量隐球菌。
隐球菌是溶骨性骨病变的罕见病因，可能会被误诊为恶性肿瘤。在罕见情况下，广泛的骨膜反应可能支持原发性骨恶性肿瘤的放射学诊断。可采用FNA并检查Diff-Quik染色玻片来区分隐球菌性骨髓炎和恶性肿瘤，并迅速鉴定病原体。
