Iida A, Takagi R, Hoshina H, Ono K, Kaji M, Tsurumaki H, Fukuda J, Nagashima K, Miyaura Y, Hayatsu M, Miyamoto T
Second Dept. of Oral and Maxillofacial Surgery, Faculty of Dentistry, Niigata University.
Gan To Kagaku Ryoho. 2000 Sep;27(10):1527-32.
UFT was administered orally at a dosage of 200 mg/day, 2 times a day, to patients over 80 years of age with oral cancer. The concentration of 5-FU in the serum and tumor tissue, as well as the side effects, were investigated. The results were as follows: 1. The concentration of 5-FU in the serum peaked (0.017 to 0.066 microgram/ml) 1 or 2 hours after UFT administration. The concentration 8 hours after administration was relatively high (0.016 to 0.041 microgram/ml). 2. The 5-FU concentrations in the tumor tissues in 3 out of 5 cases were greater than 0.05 microgram/g, which is considered to be the effective level. The concentration tended to be higher with increased duration of administration. 3. A minor side effect, bone marrow dysfunction, was observed. No effect on the function of the liver or digestive system was observed.
对80岁以上的口腔癌患者口服优福定（UFT），剂量为每日200毫克，分两次服用。对血清和肿瘤组织中的5-氟尿嘧啶（5-FU）浓度以及副作用进行了研究。结果如下：1. 口服UFT后1至2小时，血清中5-FU浓度达到峰值（0.017至0.066微克/毫升）。给药8小时后的浓度相对较高（0.016至0.041微克/毫升）。2. 5例中有3例肿瘤组织中的5-FU浓度大于0.05微克/克，这被认为是有效水平。随着给药时间的延长，浓度有升高趋势。3. 观察到轻微的副作用，即骨髓功能障碍。未观察到对肝脏或消化系统功能的影响。
