Oiwa T, Saito H
Gan To Kagaku Ryoho. 1986 Mar;13(3 Pt 1):525-30.
Concentration of FT-207, 5-FU and Uracil in blood and normal lung tissue were estimated for lung cancer patients to whom UFT was orally administered. The histological types of these cases were as follows: 10 squamous cell carcinomas, 10 adenocarcinomas, 2 large cell carcinomas and 1 small cell carcinoma. Average concentration of 5-FU in these tumor tissues was 0.101 +/- 0.107 microgram/g. This was a significantly higher 5-FU concentration in comparison to those in serum and normal lung tissue. Comparison of 5-FU concentration between squamous cell carcinomas and adenocarcinomas showed no significant difference. Between metastasis-positive lymph nodes and metastasis-negative lymph nodes, there was also no significant difference in 5-FU concentration, but there was a significant difference in Uracil concentration. This result showed an effective transition of 5-FU from serum to tumor tissues with oral administration of UFT. It was therefore concluded that UFT would be expected to have an antitumor effect in primary lung cancer patients.
对口服优福定（UFT）的肺癌患者，测定其血液及正常肺组织中FT - 207、5 - 氟尿嘧啶（5 - FU）和尿嘧啶的浓度。这些病例的组织学类型如下：10例鳞状细胞癌、10例腺癌、2例大细胞癌和1例小细胞癌。这些肿瘤组织中5 - FU的平均浓度为0.101±0.107微克/克。与血清及正常肺组织中的5 - FU浓度相比，该浓度显著更高。鳞状细胞癌与腺癌之间5 - FU浓度的比较未显示出显著差异。在转移阳性淋巴结与转移阴性淋巴结之间，5 - FU浓度也无显著差异，但尿嘧啶浓度存在显著差异。该结果表明口服UFT时5 - FU能有效地从血清转移至肿瘤组织。因此得出结论，优福定有望对原发性肺癌患者产生抗肿瘤作用。
