Kusama M, Kaise H, Nakayama S, Oota D, Aoki T, Koyanagi Y, Matsunaga T, Nakamura Y
3rd Dept. of Surgery, Tokyo Medical University.
Gan To Kagaku Ryoho. 2000 Sep;27(10):1573-6.
A 62-year-old woman who underwent standard radical mastectomy for left breast cancer developed pleural and pulmonary metastases 16 years later. She complained of slight dyspnea, and computed tomography of the chest revealed a tumor with marked pleural effusion. Her serum level of carcinoembryonic antigen was also increased (49 ng/ml). Systemic chemotherapy with cyclophosphamide, adriamycin, and 5-fluorouracil (CAF) was performed, but she did not show a marked response to CAF therapy. Therefore, she was orally administered UFT and CPA for 5 consecutive days followed by 2 drug-free days. Pleural disseminated foci and a lung tumor were reduced in size on chest CT and the CEA level was decreased within the normal limit. Recently, it was reported that UFT demonstrated significant antiangiogenic activity. This effect may play an important role in the efficacy seen in this patient.
一名62岁女性因左乳腺癌接受了标准根治性乳房切除术，16年后出现胸膜和肺转移。她主诉轻微呼吸困难，胸部计算机断层扫描显示有一个伴有大量胸腔积液的肿瘤。她的癌胚抗原血清水平也升高（49 ng/ml）。采用环磷酰胺、阿霉素和5-氟尿嘧啶（CAF）进行全身化疗，但她对CAF治疗未表现出明显反应。因此，她口服优福定（UFT）和环磷酰胺（CPA），连续服用5天，随后停药2天。胸部CT显示胸膜播散病灶和肺部肿瘤缩小，癌胚抗原水平降至正常范围。最近有报道称优福定具有显著的抗血管生成活性。这种作用可能在该患者所观察到的疗效中发挥重要作用。
