Inoue K, Tabei T, Kusawake T, Sugamata N, Suemasu K, Higashi Y, Kurosumi M
Dept. of Endocrinology, Saitama Cancer Center.
Gan To Kagaku Ryoho. 2001 Feb;28(2):221-4.
A patient with lung and pleural metastases from breast cancer treated effectively with toremifene is reported. A 62-year-old woman underwent mastectomy for breast cancer, and had high levels of estrogen and progesterone receptor. After 2-years of adjuvant UFT therapy, lung and pleural metastases were seen on a chest x-ray. The patient received a high-dose of toremifene (120 mg/day). After five months with toremifene, a chest x-ray and CT scan showed the disappearance of lung and pleural metastases. No recurrence or metastases have been detected for twenty months to date. No serious side effects were noticed. High-dose toremifene might be an effective therapy for cases of postmenopausal metastatic breast cancer, with high levels of estrogen and progesterone receptor.
报告了1例乳腺癌肺和胸膜转移患者接受托瑞米芬治疗后取得有效疗效的病例。一名62岁女性因乳腺癌接受了乳房切除术，雌激素和孕激素受体水平较高。辅助使用优福定（UFT）治疗2年后，胸部X线检查发现肺和胸膜转移。患者接受了高剂量托瑞米芬（120毫克/天）治疗。使用托瑞米芬5个月后，胸部X线和CT扫描显示肺和胸膜转移灶消失。迄今为止20个月未检测到复发或转移。未观察到严重副作用。高剂量托瑞米芬可能是治疗绝经后雌激素和孕激素受体水平较高的转移性乳腺癌病例的有效疗法。
