Kikunaga H, Sotome K, Morisue A, Matsudo A, Baba H, Nakai H, Takao M, Osakabe Y, Miura H
Dept. of Surgery, Hino Municipal General Hospital.
Gan To Kagaku Ryoho. 2000 Sep;27(10):1585-91.
We report a case of advanced rectal cancer accompanied by unresectable liver metastasis in which remission has been achieved for 7 years. The patient was a 64-year-old woman, and her chief complaints were a feeling of abdominal distention and melena. After low anterior resection (D3), oral administration of 600 mg/day of UFT-E and chemotherapy against the liver metastasis by hepatic arterial injection via a reservoir were started. Since the arterial injection via a reservoir became impossible due to infection, her clinical course was observed solely with oral administration of UFT-E. As a result, complete remission was achieved 7 months postoperatively, and the patient is still alive in good health without recurrences at present (7 years postoperatively). The reason why a favorable outcome has been achieved is probably that, although the initial operation resulted is non-curative resection, measures sufficient to enable the patient to lead an ordinary social life were taken at the beginning, and efforts to achieve a long-term survival were made while respecting the quality of life of the patient so that the patient would be able to coexist with the cancer.
我们报告一例伴有不可切除肝转移的晚期直肠癌患者，其缓解状态已维持7年。患者为一名64岁女性，主要症状为腹胀和黑便。在进行低位前切除术（D3）后，开始口服每日600毫克的优福定（UFT-E），并通过储液器经肝动脉注射对肝转移灶进行化疗。由于感染，无法再通过储液器进行动脉注射，此后仅通过口服优福定（UFT-E）观察其临床病程。结果，术后7个月实现完全缓解，患者目前仍健在且身体健康，无复发（术后7年）。取得良好疗效的原因可能是，尽管初始手术为非根治性切除，但从一开始就采取了足以使患者过上正常社会生活的措施，并在尊重患者生活质量的同时努力实现长期生存，从而使患者能够与癌症共存。
