Broeckel J A, Jacobsen P B, Balducci L, Horton J, Lyman G H
Psychosocial Oncology Program and Comprehensive Breast Cancer Program, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Breast Cancer Res Treat. 2000 Jul;62(2):141-50. doi: 10.1023/a:1006401914682.
To evaluate the quality of life of breast cancer patients previously treated with adjuvant chemotherapy.
Registry data were used to recruit a sample of breast cancer patients (N = 61; mean age = 51.6 years) with no current evidence of disease who had completed adjuvant chemotherapy between 3 and 36 months earlier (average = 15.87 months). In addition, a peer nomination procedure was used to recruit an age-matched comparison group of women with no history of cancer (N = 59; mean age = 51.5 years). Both groups were mailed a survey to complete that included the Medical Outcomes Study Short Form 36 (SF-36) and the Center for Epidemiologic Studies Depression Scale (CES-D). These data were used to test the hypothesis that breast cancer patients previously treated with adjuvant chemotherapy experience impaired quality of life relative to their peers and to identify demographic and medical factors associated with individual differences in patient quality of life.
Consistent with predictions, the postchemotherapy group scored poorer than the noncancer comparison group on the CES-D and on six of the eight subscales as well as the physical component summary scale of the SF-36 (p < 0.05). With regard to individual differences in patient quality of life, younger age and unmarried status were positively related to poorer mental well-being and greater depressive symptomatology (p < 0.05). Time since cancer diagnosis and chemotherapy completion were also positively related to greater depressive symptomatology (p < 0.05). In contrast, none of the demographic or medical variables assessed were related to physical well-being (p > 0.05).
Breast cancer patients appear to experience problems in multiple quality of life domains following the completion of adjuvant chemotherapy treatment. Demographic and medical characteristics explain individual differences in mental but not physical aspects of patient quality of life. These findings demonstrate the need for interventions to improve the quality of life in breast cancer patients previously treated with adjuvant chemotherapy.
评估先前接受辅助化疗的乳腺癌患者的生活质量。
利用登记数据招募了一组乳腺癌患者样本（N = 61；平均年龄 = 51.6岁），这些患者目前没有疾病迹象，且在3至36个月前（平均 = 15.87个月）完成了辅助化疗。此外，采用同伴提名程序招募了一组年龄匹配的无癌症病史女性作为对照组（N = 59；平均年龄 = 51.5岁）。两组均收到一份调查问卷，其中包括医学结局研究简明健康状况量表（SF - 36）和流行病学研究中心抑郁量表（CES - D）。这些数据用于检验以下假设：先前接受辅助化疗的乳腺癌患者相对于其同龄人生活质量受损，并确定与患者生活质量个体差异相关的人口统计学和医学因素。
与预测一致，化疗后组在CES - D以及SF - 36的八个子量表中的六个以及身体成分汇总量表上的得分低于非癌症对照组（p < 0.05）。关于患者生活质量的个体差异，年龄较小和未婚状态与较差的心理健康和更严重的抑郁症状呈正相关（p < 0.05）。自癌症诊断和化疗完成后的时间也与更严重的抑郁症状呈正相关（p < 0.05）。相比之下，所评估的人口统计学或医学变量均与身体健康无关（p > 0.05）。
乳腺癌患者在完成辅助化疗后，似乎在多个生活质量领域存在问题。人口统计学和医学特征解释了患者生活质量在心理而非身体方面的个体差异。这些发现表明需要采取干预措施来改善先前接受辅助化疗的乳腺癌患者的生活质量。
