Cardoso-Peña Elías, Soto Pina Alexandra E, Villanueva Ángel Gómez, López Chavez Gerardo Emilio, Ramírez Martínez Pablo, Ramírez Montoya Humberto, Berumen Lechuga María Guadalupe, Benitez Arciniega Alejandra Donají, Alarcón Fortepiani María de Lourdes, Valdés Ramos Roxana, Garduño García José de Jesús
Family Medicine Unit No. 220, Mexican Institute of Social Security, Toluca, Mexico.
School of Medicine, Autonomous University of the State of Mexico, Toluca, Mexico.
Int J Endocrinol. 2020 Dec 9;2020:8874916. doi: 10.1155/2020/8874916. eCollection 2020.
Breast cancer (BC) is the first cause of cancer morbidity and mortality in women. This disease has been linked to obesity; however, it is not clear how fat accumulation affects women who survive breast cancer. Although the visceral adiposity index (VAI) is a marker of cardiometabolic risk and adipose tissue dysfunction, it is not clear how it changes in breast cancer survivors. The aim of this investigation was to compare VAI in women with and without breast cancer.
A case-control cross-sectional study was conducted on women who were BC survivors and women without the history of BC (control group). Body composition was assessed using electrical bioimpedance while VAI by means of waist circumference (WC), body mass index (BMI), triacylglycerols (TG), and high-density lipoprotein cholesterol (HDL-C).
49 women in the BC survivor group and 50 in the control group. WC was wider in the survivor group as regards control (93.65 ± 10.48 vs. 88.52 ± 9.61 cm) (=0.025); at once, TG and VAI were significantly higher for the survivor group (243.55 ± 199.84 vs. 159.84 ± 75.77) (=0.007) and (11.03 ± 11.15 vs. 6.41 ± 3.66) ( < 0.005), respectively. Body composition parameters were similar in both groups.
VAI is higher in women who are BC survivors in comparison with controls matched by age and bodyweight.
乳腺癌（BC）是女性癌症发病率和死亡率的首要原因。这种疾病与肥胖有关；然而，脂肪堆积如何影响乳腺癌存活者尚不清楚。尽管内脏脂肪指数（VAI）是心脏代谢风险和脂肪组织功能障碍的标志物，但乳腺癌存活者的VAI如何变化尚不清楚。本研究的目的是比较患乳腺癌和未患乳腺癌女性的VAI。
对乳腺癌存活者和无乳腺癌病史的女性（对照组）进行了一项病例对照横断面研究。使用生物电阻抗评估身体成分，通过腰围（WC）、体重指数（BMI）、甘油三酯（TG）和高密度脂蛋白胆固醇（HDL-C）计算VAI。
乳腺癌存活者组有49名女性，对照组有50名女性。与对照组相比，存活者组的WC更宽（93.65±10.48 vs. 88.52±9.61 cm）（P=0.025）；同时，存活者组的TG和VAI显著更高（分别为243.55±199.84 vs. 159.84±75.77）（P=0.007）和（11.03±11.15 vs. 6.41±3.66）（P<0.005）。两组的身体成分参数相似。
与年龄和体重匹配的对照组相比，乳腺癌存活者的VAI更高。
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