β2 - 肾上腺素能受体基因的Gln27Glu和Arg16Gly多态性与日本男性的肥胖无关。
Gln27Glu and Arg16Gly polymorphisms of the beta2-adrenergic receptor gene are not associated with obesity in Japanese men.
作者信息
Hayakawa T, Nagai Y, Kahara T, Yamashita H, Takamura T, Abe T, Nomura G, Kobayashi K
机构信息
Department of Internal Medicine, School of Medicine, Kanazawa University, Japan.
出版信息
Metabolism. 2000 Sep;49(9):1215-8. doi: 10.1053/meta.2000.8622.
The beta2-adrenergic receptor (beta2AR), beta3AR, or uncoupling protein 1 (UCP1) may play a pathogenic role in obesity. In Swedish Caucasians, a polymorphism at codon 27 (Gln27Glu) of the beta2AR gene was shown to be associated with obesity, but no such association was shown for a polymorphism of codon 16 (Arg16Gly). Thus, we investigated whether these polymorphisms contribute to obesity in 210 Japanese men. The frequencies of the Gln27Glu and Arg16Gly polymorphisms were 0.05 and 0.48, respectively, and there was no association with obesity. A strong linkage disequilibrium between the Gln27Glu and Arg16Gly polymorphisms was shown, but there was no apparent additive effect on the clinical or metabolic characteristics. Our results suggest that the Gln27Glu and Arg16Gly polymorphisms of the beta2AR gene are not a major contributing factor to obesity in Japanese men.
β2-肾上腺素能受体（β2AR）、β3AR或解偶联蛋白1（UCP1）可能在肥胖症中发挥致病作用。在瑞典高加索人中，β2AR基因第27位密码子（Gln27Glu）的多态性与肥胖症相关，但第16位密码子（Arg16Gly）的多态性未显示出这种关联。因此，我们在210名日本男性中研究了这些多态性是否与肥胖症有关。Gln27Glu和Arg16Gly多态性的频率分别为0.05和0.48，且与肥胖症无关联。Gln27Glu和Arg16Gly多态性之间显示出很强的连锁不平衡，但对临床或代谢特征没有明显的累加效应。我们的结果表明，β2AR基因的Gln27Glu和Arg16Gly多态性不是日本男性肥胖症的主要促成因素。
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