β2肾上腺素能受体基因中Gln27Glu和Arg16Gly多态性与肥胖易感性的关联：一项荟萃分析。
Association of Gln27Glu and Arg16Gly polymorphisms in Beta2-adrenergic receptor gene with obesity susceptibility: a meta-analysis.
作者信息
Zhang Hongxiu, Wu Jie, Yu Lipeng
机构信息
Department of Obstetrics and Gynecology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Department of Obstetrics and Gynecology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China; State Key Laboratory of Reproductive Medicine, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
出版信息
PLoS One. 2014 Jun 24;9(6):e100489. doi: 10.1371/journal.pone.0100489. eCollection 2014.
BACKGROUND
The beta2-adrenergic receptor (ADRB2) gene polymorphism has been implicated in susceptibility to obesity, but study results are still controversial.
OBJECTIVE
The present meta-analysis is performed to determine whether there are any associations between the Gln27Glu (rs1042714) or the Arg16Gly (rs1042713) polymorphisms in ADRB2 and obesity susceptibility.
METHODS
The PubMed (1950-2014), Embase (1974-2014), and China National Knowledge Infrastructure (CNKI, 1994-2014) databases were searched using the search terms ("Beta2-adrenergic receptor", "β2-adrenergic receptor" or "ADRB2"), "polymorphism," and "obesity". Fixed- or random-effects pooled measures were determined on the bias of heterogeneity tests across studies. Publication bias was examined by Egger's test and the modified Begg's test.
RESULTS
Eighteen published articles were selected for meta-analysis. Overall analyses showed that rs1042714 (Gln27Glu) was associated with significantly increased obesity risk in the heterozygote model (Gln/Glu vs. Gln/Gln: OR: 1.16, 95% CI: 1.04-1.30, I2 = 49%, P = 0.009) and the dominant model (Gln/Glu + Glu/Glu vs. Gln/Gln: OR: 1.2, 95% CI: 1.00-1.44, I2 = 55%, P = 0.04), whereas no significant association was found in the other models for rs1042714. Also, no significant association was found between the rs1042713 (Arg16Gly) gene polymorphism and the risk of obesity in all genetic models. In addition, neither rs1042713 (Arg16Gly) nor rs1042714 (Gln27Glu) showed any significant association with obesity susceptibility when the population were stratified based on gender.
CONCLUSION
Our meta-analysis revealed that the rs1042714 (Gln27Glu) polymorphism is associated with obesity susceptibility. However, our results do not support an association between rs1042713 (Arg16Gly) polymorphisms and obesity in the populations investigated. This conclusion warrants confirmation by more case-control and cohort studies.
背景
β2-肾上腺素能受体（ADRB2）基因多态性与肥胖易感性有关，但研究结果仍存在争议。
目的
进行本次荟萃分析以确定ADRB2基因中的Gln27Glu（rs1042714）或Arg16Gly（rs1042713）多态性与肥胖易感性之间是否存在关联。
方法
使用检索词（“Beta2-肾上腺素能受体”、“β2-肾上腺素能受体”或“ADRB2”）、“多态性”和“肥胖”检索PubMed（1950 - 2014年）、Embase（1974 - 2014年）和中国知网（CNKI，1994 - 2014年）数据库。根据各研究间异质性检验的偏倚确定固定效应或随机效应合并测量值。通过Egger检验和改良的Begg检验检查发表偏倚。
结果
选择18篇已发表文章进行荟萃分析。总体分析表明，rs1042714（Gln27Glu）在杂合子模型（Gln/Glu与Gln/Gln比较：OR：1.16，95%CI：1.04 - 1.30，I2 = 49%，P = 0.009）和显性模型（Gln/Glu + Glu/Glu与Gln/Gln比较：OR：1.2，95%CI：1.00 - 1.44，I2 = 55%，P = 0.04）中与肥胖风险显著增加相关，而在rs1042714的其他模型中未发现显著关联。此外，在所有遗传模型中，rs1042713（Arg16Gly）基因多态性与肥胖风险之间未发现显著关联。另外，当按性别对人群进行分层时，rs1042713（Arg16Gly）和rs1042714（Gln27Glu）均未显示与肥胖易感性有任何显著关联。
结论
我们的荟萃分析表明，rs1042714（Gln27Glu）多态性与肥胖易感性相关。然而，我们的结果不支持在所研究人群中rs1042713（Arg16Gly）多态性与肥胖之间存在关联。这一结论有待更多病例对照研究和队列研究予以证实。
Zotero 插件