一种跨膜CXC趋化因子是HIV共受体Bonzo的配体。

A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo.

作者信息

Matloubian M, David A, Engel S, Ryan J E, Cyster J G

机构信息

Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143, USA.

出版信息

Nat Immunol. 2000 Oct;1(4):298-304. doi: 10.1038/79738.

DOI:10.1038/79738

PMID:11017100

Abstract

We describe a protein with the hallmarks of a chemokine, designated CXCL16, that is made by dendritic cells (DCs) in lymphoid organ T cell zones and by cells in the splenic red pulp. CXCL16 contains a transmembrane domain and both membrane-bound and soluble forms are produced. Naïve CD8 T cells, natural killer T cells and a subset of memory CD4 T cells bind CXCL16, and activated T cells migrated chemotactically to the soluble chemokine. By expression cloning, Bonzo (also known as STRL33 and TYMSTR) was identified as a CXCL16 receptor. CXCL16 may function in promoting interactions between DCs and CD8 T cells and in guiding T cell movements in the splenic red pulp. CXCL16 was also found in the thymic medulla and in some nonlymphoid tissues, indicating roles in thymocyte development and effector T cell trafficking.

摘要

我们描述了一种具有趋化因子特征的蛋白质，命名为CXCL16，它由淋巴器官T细胞区的树突状细胞（DC）和脾红髓中的细胞产生。CXCL16含有一个跨膜结构域，可产生膜结合形式和可溶性形式。初始CD8 T细胞、自然杀伤T细胞和一部分记忆CD4 T细胞可结合CXCL16，活化的T细胞可向可溶性趋化因子进行趋化迁移。通过表达克隆，Bonzo（也称为STRL33和TYMSTR）被鉴定为CXCL16受体。CXCL16可能在促进DC与CD8 T细胞之间的相互作用以及引导T细胞在脾红髓中的移动中发挥作用。在胸腺髓质和一些非淋巴组织中也发现了CXCL16，表明其在胸腺细胞发育和效应T细胞迁移中发挥作用。