Farenc C, Fabreguette J R, Bressolle F
Laboratoire de Pharmacocinétique Clinique, Faculté de Pharmacie, Université Montpellier I, France.
Comput Biomed Res. 2000 Oct;33(5):315-29. doi: 10.1006/cbmr.2000.1548.
This paper presents a new software, Pk-fit, to fit nonlinear models to kinetic and dynamic data. Directly connected to the spreadsheet, a statistical software component manager is available. In the data manager, Pk-fit includes the noncompartmental analysis module, the compartmental analysis module, the nonlinear kinetic process module, the drug absorption module, the pharmacodynamic data modeling module, the simultaneous fitting module, and the user-defined library module. In this paper, we present a detailed comparison of the kinetic analysis using Pk-fit and common software packages, PCNONLIN, MODFIT, MKMODEL, NONMEM, and SIPHAR, based on the textbook published by Gabrielsson in 1992, "Compilation of Analyzed Data Sets for Pharmacokinetic Software Evaluation." The comparison of Pk-fit with the reference softwares revealed that the parameters and their dispersion found with Pk-fit are consistent with the ones estimated with the other programs. In conclusion, Pk-fit constituted a valid tool for pharmacokinetic/pharmacodynamic data analysis.
本文介绍了一种名为Pk-fit的新软件，用于将非线性模型拟合到动力学和动态数据。它直接连接到电子表格，有一个统计软件组件管理器。在数据管理器中，Pk-fit包括非房室分析模块、房室分析模块、非线性动力学过程模块、药物吸收模块、药效学数据建模模块、同时拟合模块和用户定义库模块。本文基于Gabrielsson于1992年出版的教科书《用于药代动力学软件评估的分析数据集汇编》，对使用Pk-fit与常用软件包PCNONLIN、MODFIT、MKMODEL、NONMEM和SIPHAR进行的动力学分析进行了详细比较。Pk-fit与参考软件的比较表明，Pk-fit得出的参数及其离散度与其他程序估计的参数一致。总之，Pk-fit是药代动力学/药效学数据分析的有效工具。
