Olivari V N, Olivari B
Arzneimittelforschung. 1975 May;25(5):745-8.
Using a standardized procedure we have experimented on rats in order to examine the rate of necrosis in pedicle flaps in conjunction with 3,7-dimethyl-1-(5-oxo-hexyl)-xanthine (pentoxifyline, Trental) and dextran 40. Compared with the control group and that treated with dextran 40 the group treated with Trental showed significant decrease in necroses. The influence of drugs on blood supply demonstrated in this srudy as being significant is discussed.
我们采用标准化程序对大鼠进行实验，以研究3,7-二甲基-1-(5-氧代己基)-黄嘌呤（己酮可可碱，曲克芦丁）和右旋糖酐40对带蒂皮瓣坏死率的影响。与对照组和右旋糖酐40治疗组相比，己酮可可碱治疗组的坏死率显著降低。本文讨论了本研究中所证明的药物对血液供应的显著影响。
