Miyamoto K, Ito M, Segawa H, Kuwahata M
Department of Nutritional Science, University of Tokushima School of Medicine, Japan.
J Med Invest. 2000 Aug;47(3-4):118-22.
Retention of inorganic phosphate (Pi) and associated hyperphosphatemia are important development of hyperparathyroidism secondary to renal failure. The beneficial effect of a low-Pi diet in the prevention of hyperparathyroidism can be attributed to the decrease in PTH secretion. This effect of Pi may be mediated by specific molecules in the parathyroid cell membrane. A complementary DNA encoding a Na(+)-Pi co-transporter, termed rat PiT-1, has been isolated from rat parathyroid. The amount of PiT-1 mRNA in the parathyroid is controlled by vitamin D and dietary Pi, which are the most important regulators of PTH secretion. The parathyroid Pi transporter may mediate the effects of extracellular Pi and PTH secretion in secondary hyperparathyroidism. In this study, we focus on the function of Na/Pi co-transporters in the parathyroid glands as inorganic Pi sensor.
无机磷酸盐（Pi）潴留及相关的高磷血症是肾衰竭继发性甲状旁腺功能亢进的重要发展过程。低磷饮食在预防甲状旁腺功能亢进方面的有益作用可归因于甲状旁腺激素（PTH）分泌的减少。Pi的这种作用可能由甲状旁腺细胞膜中的特定分子介导。一种编码Na(+)-Pi共转运体的互补DNA，称为大鼠PiT-1，已从大鼠甲状旁腺中分离出来。甲状旁腺中PiT-1 mRNA的量受维生素D和饮食Pi的控制，而维生素D和饮食Pi是PTH分泌的最重要调节因子。甲状旁腺Pi转运体可能介导细胞外Pi和继发性甲状旁腺功能亢进中PTH分泌的作用。在本研究中，我们聚焦于甲状旁腺中作为无机Pi传感器的Na/Pi共转运体的功能。
